Abstract
The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups.
TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four
main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for
prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses
on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort
has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according
to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the
rationale and design of the study, summarizes its fndings, and outlines the objectives for precision medicine.